Long term survival and disease burden from out-of-hospital cardiac arrest: a population-based cohort study

Abstract Background Long-term outcomes of out-of-hospital cardiac arrest (OHCA) are important to evaluate the overall health burden OHCA on society. The concept disability-adjusted life years (DALY) have recently been utilised measure disease in OHCA, but data an Asian cohort remains limited. We aimed quantify and identify predictors long-term survival (up 10 follow up) patients with as well annual estimated using DALY a national multi-ethnic cohort. Methods conducted open study through linkage Pan-Asian Resuscitation Outcomes Study Singapore Registry Births Deaths from 2010 2020 [1]. quantified standardised mortality ratio (SMR) for each year up DALY. Predictors were identified cox-proportional hazards models. Kaplan-Meier curves constructed population, by key characteristics. proportion surviving (and 95% CI) was calculated eight post-OHCA. Results included 802 cases analysis. mean age 56.0 (SD 17.8), 631 (78.7%) male, majority (552 cases, 68.8%) Chinese ethnicity (Table 1). at one 0.84 (95% CI: 0.81–0.87), five 0.68 CI 0.65–0.72), ten 0.62 0.57–0.67) (Figure Age (HR 1.03, 1.02–1.04, p<0.001), shockable first rhythm 0.75, 0.52–0.93, p=0.015) Cerebral Performance Category (CPC) 4.62, 3.17–6.75, p<0.001) independently associated 2, 3). At year, SMR 14.9 12.5–17.8), this decreased 1.2 0.7–1.8) three years, 0.4 0.2–0.8) 4). top causes death after based ICD10 categories pneumonia, chronic ischemic heart disease, acute myocardial infarction. total increased 304.1 849.7 2015, followed decreasing 547.1 2018. 12.162 3.599 Conclusions CPC category higher risk mortality, while lower survivors. Initial survivors rate compared general population normalises that subsequently, showed trends Further improvements surveillance management may be warranted improve survivorship decrease globally. Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): Medical Research Council, Clinician Scientist Award, (NMRC/CSA/024/2010 NMRC/CSA/0049/2013), Ministry Health, Health Services Grant, (HSRG/0021/2012)